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Neonatal screening for congenital adrenal hyperplasia using 17-hydroxyprogesterone assay in filter paper blood spots
A Larsson1, L Hagenfeldt, U von Döbeln
1Department of Bacteriology, National Bacteriological Laboratory, Stockholm, Sweden.
Hormone Research
|January 1, 1988
Abstract:
Screening of infants for congenital adrenal hyperplasia (CAH) using filter paper blood samples collected on the 5th day of life was performed with a radioimmunoassay for 17-hydroxyprogesterone without extraction with organic solvents. A total of 153,000 newborns were screened and 12 cases of CAH were detected (1:12,800). With recall levels related to gestational age, the recall rate could be lowered to 0.05%.