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Concurrence of multiple sclerosis and primary biliary cholangitis: Report of 3 cases
Mozhgan Sattar1, Maryam Poursadeghfard1
1Clinical Neurology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Background:
Multiple sclerosis (MS) is an autoimmune disorder of the central nervous system which damages the myelin and axon. Primary biliary cholangitis (PBC) is a slow progressive liver disease with autoimmune feature in which non-purulent destructive cholangitis and interlobular bile duct destruction occur. Involvement of each of PBC and MS is thought to be related to environmental exposure in genetically susceptible persons.
Case Presentation:
Here, we aim to report 3 women 52, 27 and 51 years old with MS and PBC.
Conclusion:
Although MS seems to have an association with some autoimmune gastrointestinal disorders such as ulcerative colitis, the concurrence of MS and PBC has been rarely reported.
Insights
Multiple sclerosis (MS) and primary biliary cholangitis (PBC) are autoimmune disorders. This report details three women diagnosed with both MS and PBC, highlighting a rare concurrence of these conditions.
Area of Science:
- Neuroimmunology
- Hepatology
- Autoimmune Diseases
Background:
- Multiple sclerosis (MS) is a central nervous system autoimmune disorder targeting myelin and axons.
- Primary biliary cholangitis (PBC) is a chronic autoimmune liver disease characterized by bile duct destruction.
- Both MS and PBC are linked to environmental factors in genetically susceptible individuals.
Observation:
- The study presents three female patients diagnosed with both MS and PBC.
- Patient ages were 52, 27, and 51 years old.
- This case series focuses on the rare co-occurrence of these two distinct autoimmune conditions.
Findings:
- The concurrence of MS and PBC is infrequently documented in medical literature.
- While MS is associated with some autoimmune gastrointestinal conditions, its co-occurrence with PBC is particularly rare.
- This report adds to the limited existing data on patients with both MS and PBC.
Implications:
- Understanding the link between MS and PBC may offer insights into shared autoimmune mechanisms.
- Further research is warranted to explore potential common etiologies or risk factors for MS and PBC.
- This case series may inform clinical awareness and diagnostic considerations for patients presenting with overlapping autoimmune symptoms.
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