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Experimental carbon tetrachloride-induced cirrhosis of the liver
E Muñoz Torres1, J I Paz Bouza, M M Abad Hernandez
1Department of Pathology, School of Medicine, University of Salamanca, Spain.
International Journal of Tissue Reactions
|January 1, 1988
Abstract:
The authors produced an experimental model of cirrhosis by administering carbon tetrachloride (CCl4) intraperitoneally over 46 weeks to female Wistar rats at a dose of 0.2 ml of a solution of CCl4 in 33% mineral oil. The cytotoxic effect on the liver of this substance was evaluated in different developmental stages of the process by macroscopic, microscopic and ultrastructural studies.