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Related Experiment Video

Updated: Dec 19, 2025

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Waldenstrom's Macroglobulinemia: A case report.

Nejima Kolikkat1, Shamsudeen Moideen2, Aysha Khader1

  • 1Department of Pathology, Iqraa International Hospital and Research Centre, Calicut, Kerala, India.

Journal of Family Medicine and Primary Care
|June 9, 2020
PubMed
Summary

Waldenstrom's macroglobulinemia (WM) is a rare lymphoma. This case highlights a patient with atypical WM presentation, emphasizing the need for comprehensive diagnostics for accurate diagnosis and effective treatment.

Keywords:
Immunoglobulin M monoclonal gammopathyWaldenstrom macroglobulinemialymphoplasmacytic

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Area of Science:

  • Hematology
  • Oncology
  • Immunology

Background:

  • Waldenstrom's macroglobulinemia (WM) is a rare, slow-progressing lymphoplasmacytic lymphoma.
  • It typically presents with constitutional symptoms, organomegaly, cytopenias, and hyperviscosity syndrome.
  • The neoplasm involves bone marrow, characterized by small lymphocytes, plasmacytoid lymphocytes, plasma cells, and immunoglobulin M (IgM) gammopathy.

Observation:

  • A 60-year-old male presented with anemia and fatigue, lacking common WM signs like lymphadenopathy or organomegaly.
  • Diagnosis was confirmed via bone marrow examination (morphological and immunohistochemical) and elevated serum IgM.
  • The patient showed a positive response to plasmapheresis and chemotherapy.

Findings:

  • This case represents an unusual presentation of WM, deviating from typical clinical features.
  • Comprehensive hematological workup, including serum electrophoresis, bone marrow biopsy, and immunohistochemistry, is crucial.
  • Accurate diagnosis is essential for differentiating WM from other lymphoid neoplasms and plasma cell disorders.

Implications:

  • Highlights the importance of considering atypical presentations in diagnosing rare hematological malignancies.
  • Underscores the diagnostic value of integrated morphological, immunohistochemical, and serological assessments.
  • Emphasizes the need for tailored treatment strategies based on accurate diagnosis in WM patients.