Zinc-Containing Metalloenzymes: Inhibition by Metal-Based Anticancer Agents
Ruirong Ye1,2, Caiping Tan2, Bichun Chen1
1Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, China.
Frontiers in Chemistry
|June 9, 2020
Summary
Platinum anticancer drugs cause side effects and resistance. This review explores novel metal-based agents targeting zinc enzymes like HDACs, CAs, and MMPs, offering new cancer treatment strategies.
Area of Science:
- Medicinal Chemistry
- Biochemistry
- Oncology
Background:
- Platinum-based anticancer drugs target DNA, leading to significant side effects and drug resistance.
- Zinc-containing metalloenzymes are crucial in cancer development and represent promising alternative therapeutic targets.
- Metal complexes offer unique advantages for enzyme inhibition due to their structural versatility and tunable properties.
Purpose of the Study:
- To review recent advancements in metal-based anticancer agents targeting zinc-containing metalloenzymes.
- To highlight the potential of inhibiting specific zinc enzymes overexpressed in tumors.
Main Methods:
- Literature review of metal-based anticancer agents and their mechanisms of action.
- Focus on inhibition of histone deacetylases (HDACs), carbonic anhydrases (CAs), and matrix metalloproteinases (MMPs).
Main Results:
- Metal complexes can be designed with high selectivity and affinity for enzyme targets.
- The photophysical, photochemical, and redox properties of metal complexes enable multi-modal inhibition strategies.
- Several metal-based agents show promise in targeting key zinc enzymes implicated in cancer.
Conclusions:
- Zinc-containing metalloenzymes are viable targets for novel metal-based anticancer therapies.
- Metal complexes offer a promising platform for developing next-generation cancer treatments with improved efficacy and reduced side effects.
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