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Updated: Dec 19, 2025

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Naturally occurring [4 + 2] type terpenoid dimers: sources, bioactivities and total syntheses
Bo Liu1, Shaomin Fu, Chengying Zhou
1Key Laboratory of Green Chemistry & Technology of the Ministry of Education, College of Chemistry, Sichuan University, 29 Wangjiang Rd., Chengdu, Sichuan 610064, China. chembliu@scu.edu.cn.
Abstract:
Covering: up to January 2020[4 + 2] type terpenoid dimers are natural products biosynthetically derived from [4 + 2] cycloaddition between two terpenoid monomers. They have attracted the attention of scientists due to their complex architectures, biological activities, natural production pathways and synthetic challenges. In this review article, we highlight recent research progress on naturally occurring [4 + 2] type terpenoid dimers, including their sources, bioactivities, biosynthetic hypotheses and total chemical syntheses.
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