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Updated: Dec 19, 2025

Human Neural Organoids for Studying Brain Cancer and Neurodegenerative Diseases
Published on: June 28, 2019
Neuronal signatures in cancer
Erik Jung1,2, Julieta Alfonso3, Hannah Monyer3,4
1Neurology Clinic and National Center for Tumor Diseases, University Hospital Heidelberg, Heidelberg, Germany.
Cancer Neuroscience research reveals tumor cells form networks using neurite-like tumor microtubes (TMs) to resist therapy. This field explores neuronal characteristics in cancers beyond the brain for new treatment strategies.
Area of Science:
- Oncology and Neuroscience
- Cancer Biology
Background:
- Advances in solid tumor treatment have not improved prognosis for brain tumors.
- Cancer Neuroscience is an emerging field integrating oncology and neuroscience.
- Glioblastoma (GB) cells form tumor microtubes (TMs) for therapy resistance.
Purpose of the Study:
- To review neurite-like protrusions and neurodevelopmental aspects in cancer.
- To explore the role of Cancer Neuroscience in developing novel therapies.
Main Methods:
- Review of current literature on tumor microtubes and neurodevelopment in cancer.
- Analysis of single cell sequencing data revealing neuronal characteristics in tumors.
Main Results:
- GB cells extend tumor microtubes (TMs) to form networks and retrieve neuronal input.
- Tumor cells, including those of epithelial origin, exhibit neuronal characteristics.
- Primary brain tumors share similarities with neurodevelopmental processes.
Conclusions:
- Cancer Neuroscience offers a new framework for understanding and treating various cancers.
- Neuronal characteristics and interactions are crucial in tumor progression and therapy resistance.
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