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Updated: Dec 19, 2025
08:32
Adapting Human Videofluoroscopic Swallow Study Methods to Detect and Characterize Dysphagia in Murine Disease Models
Published on: March 1, 2015
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Myopathies featuring early or prominent dysphagia
James D Triplett1, Marcus V Pinto1, Emily A Hosfield2
1Division of Neuromuscular Medicine, Department of Neurology, Mayo Clinic, Rochester, Minnesota.
Muscle & Nerve
|June 9, 2020
Summary
Myopathies can present with early or severe dysphagia, most commonly inclusion body myositis (IBM) and immune-mediated necrotizing myopathy (IMNM). Rapidly progressing dysphagia in these myopathies may indicate a positive response to immunotherapy.
Area of Science:
- Neurology
- Rheumatology
- Genetics
Background:
- Dysphagia is an understudied symptom in myopathies.
- Limited data exist on myopathies presenting with early or severe swallowing difficulties.
Purpose of the Study:
- To identify and characterize myopathy patients with initial or disproportionately severe dysphagia.
- To investigate potential predictors of treatment response in these patients.
Main Methods:
- Retrospective study of myopathy patients from January 2003 to August 2019.
- Analysis of patient demographics, diagnoses, dysphagia severity, and treatment outcomes.
Main Results:
- Thirty-two patients were identified, with a median age of 65.
- Inclusion body myositis (IBM) and immune-mediated necrotizing myopathy (IMNM) were the most common diagnoses.
- Significant dysphagia burden observed, with many requiring diet modification, feeding tubes, or experiencing aspiration pneumonia.
Conclusions:
- IBM and IMNM are key diagnoses in myopathies with prominent dysphagia.
- Rapidly progressive dysphagia may predict a favorable response to immunosuppressive therapies.
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