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Updated: Dec 19, 2025
Basophil Activation Test for Allergy Diagnosis
Published on: May 31, 2021
Increased number and activation of peripheral basophils in adult-onset minimal change disease
Huanqin Han1,2, Yong-Zhi Xu2, Shuzhen Liao2
1Infectious Diseases Center, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.
Abstract:
Nowadays, the pathogenesis of minimal change disease (MCD) is still not well-known, and the current understanding on MCD is mainly based on data derived from children, and very few adults. Here, we comprehensively analysed the correlation between the changes of peripheral basophils and the incidence rate and relapse of adult-onset MCD. The results showed that in patients at the onset of MCD, the ratio and activation of basophils were all higher than those of healthy controls (all P < .05). In vitro test results showed that basophils from healthy controls can be activated by the serum taken from patients with MCD. Among 62 patients at the onset of MCD, with complete remission after treatment and 1 year of follow-up, the relative and absolute basophil counts before treatment were higher in the long-term remission group (n = 33) than that of the relapse group (n = 29). The basophil counts were significantly higher in the infrequent relapse group (n = 13) than that of the frequent relapse group (n = 16; P < .05). These findings suggested that basophil may play a pathogenic role in adult-onset MCD, and the increased number and activation of peripheral basophils could predict recurrence in adult MCD.
Insights
Peripheral basophils, immune cells, are implicated in adult minimal change disease (MCD) pathogenesis. Elevated basophil counts and activation at onset may predict MCD relapse in adults.
Area of Science:
- Nephrology
- Immunology
Background:
- Minimal change disease (MCD) pathogenesis remains poorly understood, particularly in adults.
- Existing research primarily focuses on pediatric MCD, leaving a gap in adult-specific knowledge.
Purpose of the Study:
- To investigate the role of peripheral basophils in the incidence and relapse of adult-onset MCD.
- To determine if basophil changes correlate with disease activity and recurrence in adult MCD patients.
Main Methods:
- Comparative analysis of peripheral basophil counts and activation in adult MCD patients versus healthy controls.
- In vitro experiments assessing basophil activation by MCD patient serum.
- Longitudinal follow-up of MCD patients to correlate pre-treatment basophil levels with relapse rates.
Main Results:
- Patients with adult-onset MCD exhibited higher peripheral basophil ratios and activation compared to healthy individuals (P < .05).
- Serum from MCD patients activated basophils from healthy controls in vitro.
- Higher pre-treatment basophil counts were observed in patients achieving long-term remission versus those who relapsed.
- Basophil counts were significantly higher in infrequent relapsers compared to frequent relapsers (P < .05).
Conclusions:
- Peripheral basophils likely play a pathogenic role in adult-onset MCD.
- Increased peripheral basophil number and activation may serve as predictive markers for MCD recurrence in adults.
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