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Updated: Dec 19, 2025

Real-Time Fluorescent Measurement of Synaptic Functions in Models of Amyotrophic Lateral Sclerosis
Published on: July 16, 2021
Life-Saving Microscopy Method for Amyotrophic Lateral Sclerosis Patients
1Otto-von-Guericke-Universität Magdeburg, Magdeburg, Germany.
Abstract:
The submission describes in the form of a communication recent experiences with a promising new therapeutic approach for amyotrophic lateral sclerosis (ALS). This approach is based on imaging cycler microscopy that led to the discovery of ALS specific cells in the blood, which invade the pyramidal system (lateral corticospinal tract) of ALS patients, where they compress motor axons. The depletion of these cells leads to remission of clinical symptoms and demonstrates the important role of these cells in ALS. The therapy will be offered to ALS patients in licensed and certified centers (in progress). © 2020 International Society for Advancement of Cytometry.

