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Do Histologic Features Help Predict Colectomy in Pediatric Patients Presenting With Acute Severe Colitis?
Nicole Green1,2, Dale Lee1,2, Ghassan Wahbeh1,2
1Division of Gastroenterology and Hepatology, Seattle Children's Hospital, Seattle, Washington.
Summary
Histologic features of inflammation do not predict colectomy in pediatric patients with acute severe colitis. This study found no significant differences in inflammation markers between those who did and did not undergo surgery.
Area of Science:
- Pediatric Gastroenterology
- Inflammatory Bowel Disease Research
- Histopathology
Background:
- Prognostic factors for ulcerative colitis often focus on clinical and laboratory data.
- The prognostic significance of individual histologic features in acute severe colitis remains understudied.
Purpose of the Study:
- To investigate whether histologic features at presentation predict colectomy in pediatric patients with acute severe colitis.
Main Methods:
- Retrospective review of pediatric patients hospitalized with acute severe colitis (Pediatric Ulcerative Colitis Activity Index ≥65).
- Analysis of demographic data, disease duration, lab values, endoscopic findings, and histologic features.
- Comparison of patients who underwent colectomy within 90 days versus those who did not.
Main Results:
- Sixteen of 50 patients required colectomy within 90 days.
- No significant differences in age, albumin, hemoglobin, or C-reactive protein between surgery and no-surgery groups.
- Endoscopic Mayo score and various histologic features of inflammation were similar between groups.
Conclusions:
- Histologic features of inflammation at presentation do not predict 90-day colectomy in pediatric patients hospitalized with acute severe colitis.
Keywords:
acute severe colitiscolectomygastrointestinalinflammatory bowel diseasepediatriculcerative colitisMore Related Videos
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