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Related Experiment Video

Updated: Dec 19, 2025

Dynamic Monitoring of Seroconversion using a Multianalyte Immunobead Assay for Covid-19

Dynamic Monitoring of Seroconversion using a Multianalyte Immunobead Assay for Covid-19

Published on: February 16, 2022

A Modular Microarray Imaging System for Highly Specific COVID-19 Antibody Testing.

Per Niklas Hedde^1,2,3, Timothy J Abram⁴, Aarti Jain⁵

¹Department of Pharmaceutical Sciences, University of California, Irvine, Irvine, CA, USA.

Biorxiv : the Preprint Server for Biology

|June 9, 2020

Summary

This summary is machine-generated.

A new, affordable 3D-printable TinyArray imager detects SARS-CoV-2 antibodies rapidly. This portable device enables widespread COVID-19 serosurveillance in resource-limited settings.

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Last Updated: Dec 19, 2025

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Published on: April 6, 2021

Area of Science:

Medical Diagnostics
Biotechnology
Public Health

Background:

Accurate detection of SARS-CoV-2 antibodies is crucial for understanding COVID-19 epidemiology and vaccine efficacy.
Existing microarray readers are often expensive and not suitable for field deployment in low-resource settings.

Approach:

Developed a low-cost ($200), 3D-printable portable imaging platform (TinyArray imager) for reading coronavirus antigen microarrays (CoVAMs).
The platform utilizes a panel of antigens from SARS-CoV-2, SARS-1, MERS, and other respiratory viruses.
Designed for rapid, parallel testing of finger-prick blood samples in basic labs and field clinics, with results in 2-4 hours.

Key Points:

The TinyArray imager demonstrated performance comparable to a commercial microarray reader costing 100 times more.
Achieved high sensitivity and specificity in detecting antibodies against SARS-CoV-2 using COVID-19 positive and negative sera.
The portable and inexpensive nature of the device facilitates immediate deployment in areas with minimal infrastructure.

Conclusions:

This portable imaging platform enables large-scale serosurveillance for SARS-CoV-2.
Facilitates efficient containment, mitigation strategies, and aids in the development of therapeutics and vaccines.
Empowers rapid diagnostic capabilities in diverse settings, improving global public health preparedness.