Related Experiment Video
Updated: Dec 19, 2025

Engineering Antiviral Agents via Surface Plasmon Resonance
Published on: June 14, 2022
IgA MAb blocks SARS-CoV-2 Spike-ACE2 interaction providing mucosal immunity
Researchers discovered MAb362, a human IgA antibody that neutralizes SARS-CoV-2 and SARS-CoV. This antibody blocks viral entry by targeting the hACE2 receptor, offering potential for mucosal immunity against COVID-19.
Area of Science:
- Immunology
- Virology
- Infectious Diseases
Background:
- The COVID-19 pandemic necessitates novel interventions for prevention and treatment.
- Current SARS-CoV-2 vaccines and therapeutics do not specifically target or boost mucosal immunity.
Conclusions:
- MAb362 is a potent neutralizing antibody with potential therapeutic applications against SARS-CoV-2.
- SARS-CoV-2 specific IgA antibodies like MAb362 may induce crucial mucosal immunity in the respiratory tract.
- MAb362 represents a promising candidate for developing vaccines or therapeutics to enhance mucosal defense against COVID-19.
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