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Integrated sample inactivation, amplification, and Cas13-based detection of SARS-CoV-2
Jon Arizti-Sanz1,2, Catherine A Freije1,3, Alexandra C Stanton1,3
1Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA, USA.
Biorxiv : the Preprint Server for Biology
|June 9, 2020
Summary
A new diagnostic tool, SHINE (SHERLOCK and HUDSON Integration to Navigate Epidemics), detects SARS-CoV-2 RNA from unextracted samples. This rapid, sensitive, and specific test offers potential for widespread use beyond clinical settings.
Area of Science:
- Molecular diagnostics
- Epidemic control technologies
Background:
- The COVID-19 pandemic underscored the need for advanced diagnostic tools to manage disease spread.
- Current diagnostic methods can be time-consuming and require specialized laboratory infrastructure.
Conclusions:
- SHINE is a sensitive and specific diagnostic tool for SARS-CoV-2 RNA detection from unextracted samples.
- The integrated approach and user-friendly interface allow for potential deployment outside traditional laboratory settings.
- SHINE enhances diagnostic capabilities for improved epidemic navigation.
