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Bone scan in systemic amyloidosis.

R Roselló1, F Lomeña, F Pons

  • 1Department of Rheumatology, Hospital Clinic, Barcelona, Spain.

Nuclear Medicine Communications
|November 1, 1988
PubMed
Summary
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Bone scans using 99Tcm-methylene diphosphonate can detect amyloid deposits in systemic amyloidosis. Extra-osseous uptake is more common in primary amyloidosis, but absence of uptake does not exclude disease.

Area of Science:

  • Nuclear Medicine
  • Radiology
  • Oncology

Background:

  • Systemic amyloidosis involves amyloid protein deposition in organs and tissues.
  • Accurate staging and detection of amyloid infiltration are crucial for patient management.
  • Bone scintigraphy is a non-invasive imaging technique with potential for amyloid detection.

Purpose of the Study:

  • To evaluate the utility of bone scans with 99Tcm-methylene diphosphonate in detecting skeletal and extra-osseous amyloid deposits.
  • To correlate scintigraphic findings with clinical presentation in patients with systemic amyloidosis.
  • To assess the frequency of extra-osseous uptake in primary versus secondary amyloidosis.

Main Methods:

  • Thirty patients with systemic amyloidosis (6 primary, 24 secondary) underwent bone scans using 99Tcm-methylene diphosphonate.

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  • Skeletal and extra-osseous uptake of the radiotracer were analyzed.
  • Clinical and echocardiographic data were correlated with scintigraphic results.

    • Main Results:

    • Extra-osseous uptake was observed in 9 out of 30 patients (30%).
    • Higher frequency of extra-osseous uptake was noted in primary amyloidosis (5/6) compared to secondary amyloidosis (4/24).
    • Cardiac uptake was seen in only 1 of 14 suspected cases, and hepatic uptake in 2 of 6 suspected cases.

    Conclusions:

    • Bone scintigraphy can reveal amyloid deposits in organs and soft tissues.
    • Extra-osseous uptake of 99Tcm-methylene diphosphonate is a potential indicator of amyloid infiltration.
    • The absence of radiotracer uptake does not rule out the presence of amyloidosis.