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C-reactive protein: A promising biomarker for poor prognosis in COVID-19 infection

Bikash R Sahu1, Raj Kishor Kampa2, Archana Padhi3

  • 1School of Biotechnology, KIIT (Deemed to be University), Bhubaneswar, Odisha 751016, India.

Clinica Chimica Acta; International Journal of Clinical Chemistry
|June 9, 2020
PubMed

Insights

High C-reactive protein (CRP) levels indicate a greater risk of death in COVID-19 patients. This meta-analysis confirms CRP as a potential biomarker for assessing COVID-19 disease severity and patient outcomes.

Area of Science:

  • Biochemistry
  • Infectious Diseases
  • Clinical Medicine

Background:

  • COVID-19, a global pandemic, has prompted research into prognostic biomarkers.
  • C-reactive protein (CRP) has been investigated as a potential indicator of COVID-19 severity, but findings are inconsistent across studies.
  • A meta-analysis was conducted to definitively assess the association between CRP levels and COVID-19 outcomes.

Purpose of the Study:

  • To determine the prognostic value of C-reactive protein (CRP) in patients with COVID-19.
  • To analyze the association between CRP concentrations and mortality in COVID-19 patients.
  • To provide a conclusive understanding of CRP's role in predicting COVID-19 outcomes.

Main Methods:

  • A systematic literature search was performed using PubMed and Scopus databases.
  • 16 studies involving 1896 survivors and 849 non-survivors were included in the meta-analysis.
  • CRP concentrations were statistically compared between survivor and non-survivor groups.

Main Results:

  • The meta-analysis revealed a significant association between CRP levels and COVID-19 outcomes (Standard difference in means = 1.371, P = 0.000).
  • No publication bias was detected through Egger's regression analysis and funnel plot.
  • Significant heterogeneity across studies necessitated the use of a random model for analysis.

Conclusions:

  • Elevated CRP concentrations were observed in patients who died from COVID-19.
  • CRP shows promise as a reliable biomarker for assessing the lethality of COVID-19 infection.
  • Further research may solidify CRP's role in clinical decision-making for COVID-19 patients.
Abstract

Keywords:
BiomarkersCOVID-19CRPMeta-analysisNon-survivorsSurvivors

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