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Updated: Dec 19, 2025

Culturing and Manipulation of O9-1 Neural Crest Cells
Published on: October 9, 2018
Hippo signaling in regeneration and aging
1Leibniz Institute on Aging, Fritz Lipmann Institute e.V., Beutenbergstr. 11, 07745 Jena, Germany.
Abstract:
The two transcriptional coactivators YAP/TAZ act as the downstream transducers of the Hippo pathway. Recent studies have demonstrated that those two transcriptional regulators are crucial for an organism in order to induce a regenerative response upon tissue damage. In addition, YAP/TAZ are promising targets for regenerative medicine, as artificially increasing YAP/TAZ activity can be used to stimulate tissue regeneration, even in tissues that otherwise have little ability to regenerate. We will summarize here how YAP/TAZ could be used in regenerative medicine and how these two transcriptional regulators have been linked to aging so far.
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