Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Sequential growth hormone deficiency and acromegaly.

¹Department of Medicine, University College, Dublin, Ireland.

Postgraduate Medical Journal

|September 1, 1988

Summary

A patient initially treated for growth hormone deficiency due to a pituitary tumor later developed acromegaly. This unusual progression from deficiency to excess hormone levels was previously unreported in medical literature.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Top tips for the management of temporomandibular disorders.

British dental journal·2025

Same author

Saturable elimination of piperacillin in critically ill patients: implications for continuous infusion.

International journal of antimicrobial agents·2019

Same author

Re: 'Is a randomized trial of a short course of aminoglycoside added to β-lactam antibiotics for empirical treatment in critically ill patients with sepsis justified?' Pharmacokinetic/pharmacodynamic considerations.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2018

Same author

The efficacy of Dynorphin fragments at the κ, μ and δ opioid receptor in transfected HEK cells and in an animal model of unilateral peripheral inflammation.

Peptides·2017

Same author

Five-year experience of critical incidents associated with patient-controlled analgesia in an Irish University Hospital.

Irish journal of medical science·2010

Same author

Mitochondrial DNA sequence diversity in extant Irish horse populations and in ancient horses.

Animal genetics·2006

Area of Science:

Endocrinology
Neuro-oncology
Pituitary Disorders

Background:

Pituitary tumors can cause hormonal imbalances.
Growth hormone (GH) deficiency and excess are known pituitary tumor manifestations.

Observation:

A patient presented with symptoms of GH deficiency, necessitating human GH treatment.
Eight years after initial diagnosis and treatment, the same patient developed acromegaly.

Findings:

The case documents a rare sequential development of GH deficiency followed by acromegaly in a single patient with a pituitary tumor.
This represents a unique clinical progression not previously documented.

Implications:

Highlights the complex and potentially evolving nature of pituitary tumors.
Suggests the need for long-term monitoring of patients with pituitary tumors, even after initial treatment for deficiency.
May inform future diagnostic and therapeutic strategies for pituitary adenomas.

Related Experiment Videos