Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Dopamine mediated behavior and GABA influence.

P Westerling1, S Lindgren, U Höglund

  • 1Department of Medical Pharmacology, Biomedical Center, Uppsala University, Sweden.

Pharmacology, Biochemistry, and Behavior
|November 1, 1988
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hypophosphatemia attenuates improvements in vitality after intravenous iron treatment in patients with inflammatory bowel disease.

Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation·2024
Same author

Isocapnic hyperventilation provides early extubation after head and neck surgery: A prospective randomized trial.

Acta anaesthesiologica Scandinavica·2018
Same author

Evaluation of a method for isocapnic hyperventilation: a clinical pilot trial.

Acta anaesthesiologica Scandinavica·2017
Same author

Letter: the importance of dosing and baseline haemoglobin when establishing the relative efficacy of intravenous iron therapies.

Alimentary pharmacology & therapeutics·2017
Same author

Target temperature 34 vs. 36°C after out-of-hospital cardiac arrest - a retrospective observational study.

Acta anaesthesiologica Scandinavica·2017
Same author

Isocapnic hyperventilation shortens washout time for sevoflurane - an experimental in vivo study.

Acta anaesthesiologica Scandinavica·2016
Same journal

Chronic psilocin microdosing produces limited behavioral effects and does not enhance neurogenesis in rats.

Pharmacology, biochemistry, and behavior·2026
Same journal

Modulation of prefrontal NMDA receptors reveals pharmacogenetic differences between SHR and SLA16 rat strains.

Pharmacology, biochemistry, and behavior·2026
Same journal

Spontaneous oxycodone withdrawal alters behavior and oligodendrocyte-related gene expression in mice.

Pharmacology, biochemistry, and behavior·2026
Same journal

Improvement in depressive symptoms in people undergoing cognitive behavioral therapy who supplemented with probiotics: An open-label, pilot study.

Pharmacology, biochemistry, and behavior·2026
Same journal

Long-term follow-up of children with autism spectrum disorder and severe treatment-resistant behavioral symptoms treated with purified cannabidiol.

Pharmacology, biochemistry, and behavior·2026
Same journal

Fluoxetine reduces anxiety-like behavior but increases motor impairments in the early stages of a progressive model of Parkinson's disease.

Pharmacology, biochemistry, and behavior·2026
See all related articles

This study shows that GABA and dopamine systems interact to influence exploratory behavior in rats. Baclofen, a GABA agonist, enhanced dopamine-induced activity, suggesting GABA influences dopamine-mediated actions.

Area of Science:

  • Neuroscience
  • Behavioral Science
  • Pharmacology

Background:

  • Spontaneous behavior, like exploration, is crucial for understanding animal adaptation.
  • Dopaminergic and GABAergic systems are key neurotransmitter pathways in the central nervous system.
  • Previous research indicated dopamine's role in exploratory activity.

Purpose of the Study:

  • To investigate the interaction between GABA and dopaminergic mechanisms in spontaneous behavior.
  • To determine how GABAergic modulation affects dopamine-mediated exploratory activity in male rats.

Main Methods:

  • Male rats were used in an exploratory test situation.
  • The effects of apomorphine (dopamine agonist) and baclofen (GABA agonist) on behavior were assessed.
  • Baclofen pretreatment effects on apomorphine-induced activity were examined.

Related Experiment Videos

Main Results:

  • Apomorphine (low doses) facilitated investigative activity, confirming prior findings.
  • Baclofen (1.2-4.8 mg/kg) selectively increased investigative activity.
  • Baclofen pretreatment potentiated apomorphine's effect, suggesting GABA influences dopamine pathways.

Conclusions:

  • GABA mechanisms can modulate dopamine-mediated behaviors.
  • Investigative activity may be influenced by GABA neurons, dopamine neurons, or their interaction.
  • This interaction likely occurs in brain structures regulating exploratory behavior.