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Non-Coding RNA: Role in Gestational Diabetes Pathophysiology and Complications
Tiziana Filardi1, Giuseppina Catanzaro1, Stefania Mardente1
1Department of Experimental Medicine, "Sapienza" University, 00161 Rome, Italy.
International Journal of Molecular Sciences
|June 10, 2020
Summary
Non-coding RNAs (ncRNAs) play a crucial role in Gestational Diabetes Mellitus (GDM). Aberrant ncRNA expression is linked to GDM
Area of Science:
- Reproductive biology
- Metabolic disorders
- Molecular genetics
Background:
- Gestational Diabetes Mellitus (GDM) is pregnancy-induced glucose intolerance.
- GDM poses risks for maternal and offspring health.
- New diagnostic and prognostic markers for GDM are needed.
Purpose of the Study:
- To review recent findings on non-coding RNAs (ncRNAs) in GDM.
- To focus on molecular aspects and pathophysiological implications.
- To explore ncRNAs as potential GDM biomarkers.
Main Methods:
- Literature review of studies on ncRNAs and GDM.
- Analysis of molecular mechanisms.
- Examination of pathophysiological associations.
Main Results:
- Dysregulated ncRNAs (microRNAs, long non-coding RNAs, circular RNAs) are implicated in GDM.
- Altered ncRNA profiles correlate with insulin resistance, β-cell dysfunction, and GDM complications.
- ncRNA deregulation may affect offspring's long-term metabolic health.
Conclusions:
- ncRNAs are critical in GDM pathogenesis.
- Circulating and placenta-derived ncRNAs show potential as GDM biomarkers.
- ncRNA research offers insights into GDM's long-term consequences for offspring.
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