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Published on: May 10, 2022
N-Glycosylation and N-Glycan Processing in HBV Biology and Pathogenesis
Mihaela-Olivia Dobrica1, Catalin Lazar1, Norica Branza-Nichita1
1Institute of Biochemistry of the Romanian Academy, Splaiul Independentei 296, Sector 6, 060031 Bucharest, Romania.
Abstract:
Hepatitis B Virus (HBV) glycobiology has been an area of intensive research in the last decades and continues to be an attractive topic due to the multiple roles that N-glycosylation in particular plays in the virus life-cycle and its interaction with the host that are still being discovered. The three HBV envelope glycoproteins, small (S), medium (M) and large (L) share a very peculiar N-glycosylation pattern, which distinctly regulates their folding, degradation, assembly, intracellular trafficking and antigenic properties. In addition, recent findings indicate important roles of N-linked oligosaccharides in viral pathogenesis and evasion of the immune system surveillance. This review focuses on N-glycosylation's contribution to HBV infection and disease, with implications for development of improved vaccines and antiviral therapies.
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