Related Experiment Video
Updated: Dec 19, 2025
04:41
Isolation, Culture, and Characterization of Primary Dermal Fibroblasts from Human Keloid Tissue
Published on: July 28, 2023
3.1K
Location Propensity for Keloids in the Head and Neck
James C Wang1, Callie L Fort2, David B Hom3
1Department of Otolaryngology-Head and Neck Surgery, University of Cincinnati Medical Center, Cincinnati, Ohio, USA.
Facial Plastic Surgery & Aesthetic Medicine
|June 10, 2020
Summary
Facial and neck keloids cause disfigurement. Ears, jawline, and bearded areas are most prone to keloid development, while the central face is least affected.
Area of Science:
- Dermatology
- Plastic Surgery
- Otolaryngology
Background:
- Keloids on the face and neck can lead to significant disfigurement and psychological distress.
- Understanding regional predilections for keloid formation is crucial for plastic surgeons.
Purpose of the Study:
- To identify specific head and neck regions with a higher propensity for keloid development.
- To inform facial plastic surgeons about regional keloid risks.
Main Methods:
- A comprehensive literature search was conducted across PubMed, Ovid, Cochrane, and Embase databases up to January 2020.
- Two independent reviewers extracted data from 1445 identified keloid studies.
- Analysis included 1598 head and neck keloids from nine selected studies.
Main Results:
- The ear (particularly the lobule) showed the highest prevalence of keloids (53.0%).
- Submental/submandibular regions accounted for 72% of neck keloids.
- Other high-risk areas included periauricular, bearded facial regions, and the neck; the central face had the lowest risk.
Conclusions:
- The ear, periauricular areas, bearded regions, and submandibular/submental sites are most susceptible to keloid formation.
- The central face demonstrates the lowest risk for keloid development.
- Surgeons should consider regional risk factors before elective procedures in susceptible individuals.
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