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Significant association between rs28362491 polymorphism in NF-κB1 gene and coronary artery disease: a meta-analysis

Yanwei Wang1, Bianwen Wu2, Muqing Zhang1

  • 1Department of Cardiology, Hebei Province Hospital of Traditional Chinese Medicine, Zhongshan East street 389#,, Shijiazhuang, 050011, Changan District, China.

BMC Cardiovascular Disorders
|June 10, 2020
PubMed

Insights

The rs28362491 polymorphism in the NF-κB1 gene is linked to an increased risk of coronary artery disease (CAD). Individuals carrying the D allele may be more susceptible to developing CAD.

Area of Science:

  • Genetics
  • Cardiovascular Disease Epidemiology
  • Molecular Biology

Background:

  • The association between the rs28362491 polymorphism in the NF-κB1 gene and coronary artery disease (CAD) risk has yielded inconsistent results across studies.
  • This meta-analysis aims to consolidate existing evidence to determine the correlation between rs28362491 and CAD susceptibility.

Purpose of the Study:

  • To comprehensively evaluate the association between the rs28362491 polymorphism and the risk of coronary artery disease (CAD).
  • To synthesize data from multiple case-control studies to provide a robust assessment of genetic susceptibility to CAD.

Main Methods:

  • A systematic literature search was conducted across major databases (Web of Science, EMBASE, PubMed, Wanfang, CNKI) up to August 1, 2019.
  • Thirteen case-control studies, comprising 17 cohorts with 9378 cases and 10,738 controls, were included in the meta-analysis.
  • Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to quantify the association between the rs28362491 polymorphism and CAD risk across various genetic models.

Main Results:

  • The meta-analysis revealed a significant correlation between the rs28362491 polymorphism and CAD risk across five genetic models.
  • Specific findings include: D vs. I (OR=1.16), DD vs. II (OR=1.37), DI vs. II (OR=1.11), DD+DI vs. II (OR=1.17), and DD vs. DI+II (OR=1.29), all with P<0.01.
  • Significant associations persisted after stratification by ethnicity and gender, particularly in the dominant genetic model.

Conclusions:

  • The findings suggest that the mutant D allele at the rs28362491 locus is associated with an increased risk of coronary artery disease (CAD).
  • Carriers of the D allele appear to exhibit heightened susceptibility to CAD, highlighting a potential genetic risk factor.
Abstract

Keywords:
Coronary artery diseaseMeta-analysisNF-κB1PolymorphismRs28362491

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