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Related Experiment Video

Updated: Dec 19, 2025

Cutaneous Leishmaniasis in the Dorsal Skin of Hamsters: a Useful Model for the Screening of Antileishmanial Drugs

Cutaneous Leishmaniasis in the Dorsal Skin of Hamsters: a Useful Model for the Screening of Antileishmanial Drugs

Published on: April 21, 2012

Cutaneous leishmaniasis: A great imitator.

Mehmet Salih Gurel¹, Burak Tekin², Soner Uzun³

¹Department of Dermatology, Istanbul Medeniyet University, School of Medicine, Istanbul, Turkey.

Clinics in Dermatology

|June 10, 2020

Summary

Cutaneous leishmaniasis (CL) mimics many skin conditions, leading to misdiagnosis and improper treatment. Early suspicion and diagnostic tools are crucial for accurate identification and management of this great imitator.

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Area of Science:

Dermatology
Infectious Diseases
Parasitology

Background:

Cutaneous leishmaniasis (CL) is known as "the great imitator" due to its diverse clinical presentations.
Misdiagnosis of CL can result in inappropriate treatment and increased patient morbidity.
Atypical CL forms arise from parasite-host interactions or secondary infections, complicating diagnosis.

Purpose of the Study:

To emphasize the broad differential diagnosis of cutaneous leishmaniasis.
To highlight the importance of considering CL in various dermatological conditions.
To review diagnostic tools for differentiating CL from its mimics.

Main Methods:

Review of clinical presentations and differential diagnoses of CL.
Discussion of diagnostic methods including smear, histopathology, culture, and PCR.
Emphasis on clinical suspicion in endemic and non-endemic regions.

Main Results:

CL can mimic a wide range of dermatoses, including erysipelas, dermatitis, and neoplasms.
Atypical presentations necessitate a high index of suspicion for CL.
Diagnostic tools are essential for distinguishing CL from its look-alikes.

Conclusions:

Cutaneous leishmaniasis requires careful consideration due to its mimicry of other skin diseases.
Accurate diagnosis relies on clinical suspicion and appropriate laboratory investigations.
Understanding the broad differential diagnosis is key to effective CL management.