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Author Spotlight: Simple Establishment of a Vascularized Osteogenic Bone Marrow Niche Using Pre-Cast Poly(Ethylene Glycol) (PEG) Hydrogels in an Imaging Microplate
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Microfluidic-based models to address the bone marrow metastatic niche complexity.

Patrícia Ribeiro1, Luís Leitão2, Ana C Monteiro3

  • 1Instituto de Investigação e Inovação em Saúde da Universidade do Porto, Associação (i3S), 4200-135 Porto, Portugal; Instituto de Engenharia Biomédica (INEB), Universidade do Porto, 4200-135 Porto, Portugal; Faculdade de Engenharia da Universidade do Porto (FEUP), 4200-465 Porto, Portugal; Instituto de Ciências Biomédicas Abel Salazar (ICBAS), Universidade do Porto, 4050-313 Porto, Portugal.

Seminars in Cell & Developmental Biology
|June 10, 2020
PubMed
Summary

Microfluidic models offer advanced alternatives to animal testing for studying bone marrow (BM) metastasis in cancer. These in vitro systems aid in developing personalized medicine by mimicking the complex BM metastatic niche.

Keywords:
Bone marrowBone-on-a-chipMetastasesMicrofluidicTherapies

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Area of Science:

  • Oncology
  • Biomedical Engineering
  • Cancer Metastasis Research

Background:

  • Bone marrow (BM) is a common site for solid cancer metastasis, leading to significant patient morbidity and mortality.
  • Current therapies are insufficient to manage the burden of BM metastasis.
  • Microfluidic in vitro models show promise as alternatives to animal testing and for personalized medicine.

Purpose of the Study:

  • To review essential parameters for designing accurate microfluidic devices that mimic the bone marrow (BM) metastatic niche.
  • To provide a comparative analysis of existing microfluidic models for studying cancer metastasis.
  • To guide the development of advanced in vitro tools for cancer research.

Main Methods:

  • Comparative analysis of existing microfluidic platforms designed to mimic the BM metastatic niche.
  • Review of essential design parameters for in vitro microfluidic devices.
  • Examination of models addressing various stages of the metastatic cascade.

Main Results:

  • Identified key parameters crucial for accurately replicating the BM metastatic microenvironment in vitro.
  • Highlighted the diversity of microfluidic platforms developed for studying BM metastasis.
  • Provided a framework for selecting and designing appropriate microfluidic models.

Conclusions:

  • Microfluidic devices are powerful tools for studying bone marrow metastasis, offering advantages over traditional methods.
  • Accurate in vitro models are essential for understanding cancer progression and developing novel therapeutic strategies.
  • This review synthesizes critical information for advancing the design and application of microfluidic systems in oncology research.