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Related Concept Videos

General Anesthesia: Overview01:24

General Anesthesia: Overview

Anesthesia is a medical procedure that uses drugs for CNS suppression to enable painless surgeries and procedures. The selection of anesthetics is influenced by their pharmacokinetic properties, side effects, and patient characteristics. Various types of anesthesia include general, local, regional, spinal, and inhalational.
General anesthesia induces unconsciousness in the whole body, while the others target specific areas or sensations. It is administered to minimize adverse effects, maintain...
Stages of General Anesthesia01:22

Stages of General Anesthesia

Various sedation levels offer significant advantages in facilitating procedural interventions for patients undergoing medical or invasive surgical procedures. These levels span from anxiolysis to general anesthesia, providing a spectrum of sedative effects to cater to specific patient needs. Anxiolysis reduces anxiety and is achieved through minimal sedation, enabling patients to remain awake and responsive while feeling more at ease during the procedure. This level can benefit minor...
Parenteral Anesthetics: Overview01:24

Parenteral Anesthetics: Overview

Intravenous anesthetics are drugs administered parenterally to induce anesthesia or sedation. Propofol is a widely used agent formulated as a 1% emulsion in soybean oil, glycerol, and egg phosphatide. It induces rapid anesthesia primarily due to its rapid distribution from the bloodstream to target tissues and is metabolized in the liver. However, it can cause significant pain on injection and hypertriglyceridemia. Fospropofol, a water-based prodrug of propofol, lacks these adverse effects.
Inhalational Anesthetics: Overview01:20

Inhalational Anesthetics: Overview

Inhalation anesthetics are drugs that induce general anesthesia upon inhalation. They work by increasing the sensitivity of GABAA receptors or inhibiting NMDA receptors, leading to a decrease in central nervous system activity. The depth of anesthesia can be rapidly adjusted by changing the concentration of the inhaled gas. Some common examples of inhalational anesthetics include volatile liquids like isoflurane, desflurane, sevoflurane and gases like xenon and nitrous oxide. Isoflurane, a...
Sedatives and Hypnotics: Overview01:23

Sedatives and Hypnotics: Overview

Sedatives are drugs that alleviate anxiety, while hypnotics induce sleep. Both classes of medication suppress neuronal activity, leading to a calming effect for sedatives and facilitating sleep for hypnotics.
Sedative-hypnotics are categorized into barbiturates, benzodiazepines (BZDs), and non-benzodiazepines or Z-drugs. These drugs work by suppressing central nervous system activity, and this suppression is dose-dependent. Older sedative medications, like barbiturates, follow a linear curve in...
Endoscopic Procedures IV: Sigmoidoscopy and Laproscopy01:26

Endoscopic Procedures IV: Sigmoidoscopy and Laproscopy

Sigmoidoscopy and laparoscopy are distinct medical procedures that enable physicians to internally inspect different parts of the GI tract. Although they serve different purposes, each is essential for diagnosing and, in some cases, treating various medical conditions.
Sigmoidoscopy
Sigmoidoscopy is a diagnostic procedure that uses a flexible sigmoidoscope equipped with a light source and camera to examine the rectum and sigmoid colon. The procedure involves inserting the tube through the anus...

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Related Experiment Video

Updated: Jul 23, 2026

Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device
09:36

Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device

Published on: September 24, 2020

Procedural sedation in the COVID-19 era.

Nicholas Fawley1, Basem Abdelmalak2

  • 1Department of General Anesthesiology, Anesthesiology Institute, Cleveland Clinic.

Cleveland Clinic Journal of Medicine
|June 10, 2020
PubMed
Summary

Resuming procedural sedation during COVID-19 requires safety guidelines for patients and providers. Strategies include modified sedation approaches and opioid-sparing techniques to minimize transmission risks.

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Area of Science:

  • Anesthesiology
  • Infectious Disease Control
  • Healthcare Management

Background:

  • The COVID-19 pandemic necessitated a halt in elective procedures, including those requiring procedural sedation.
  • Resuming these services demands stringent safety protocols to protect both patients and healthcare professionals from viral transmission.

Purpose of the Study:

  • To provide guidelines for the safe resumption of procedural sedation services during the COVID-19 pandemic.
  • To outline modifications in sedation practices to mitigate droplet and aerosol transmission risks.

Main Methods:

  • Discussion of key considerations: timing of procedures, patient screening and testing protocols.
  • Emphasis on appropriate use of personal protective equipment (PPE) and meticulous case planning.
  • Exploration of sedative and opioid-sparing strategies, including multimodal analgesia and non-pharmacologic interventions.

Main Results:

  • Modified procedural sedation approaches can reduce the risk of droplet or aerosol transmission.
  • Decreasing nasal cannula oxygen supplementation flows is a key modification.
  • Opioid and sedative sparing strategies, alongside multimodal and non-pharmacologic approaches, reduce the need for oxygen supplementation.

Conclusions:

  • Implementing specific guidelines is crucial for safely resuming procedural sedation.
  • Adapting sedation techniques and utilizing opioid-sparing methods are vital for minimizing transmission risks.
  • Recommendations are provided for managing COVID-19 positive patients requiring procedural sedation.