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Current therapeutic possibilities of GIFT
N Garcea1, S Campo, R Dargenio
1Istituto di Clinica Ostetrica e Ginecologica, Università Cattolica del Sacro Cuore, Roma.
Acta Europaea Fertilitatis
|November 1, 1988
Summary
Gamete Intrafallopian Transfer (GIFT) shows a 19% success rate for infertility, with higher success in unexplained sterility (31%) compared to male hypofertility (10%). Optimal GIFT results require specific estradiol levels relative to follicle size.
Area of Science:
- Reproductive Medicine
- Infertility Treatments
- Assisted Reproductive Technologies
Background:
- Infertility affects numerous couples, necessitating effective treatment options.
- Various conditions, including unexplained sterility, male hypofertility, endometriosis, and tubal factors, contribute to infertility.
- Gamete Intrafallopian Transfer (GIFT) is an assisted reproductive technology used to treat infertility.
Purpose of the Study:
- To evaluate the efficacy of the Gamete Intrafallopian Transfer (GIFT) method in couples with various infertility diagnoses.
- To determine the success rates of GIFT across different pathological conditions.
- To identify optimal physiological parameters for achieving successful GIFT outcomes.
Main Methods:
- The study involved 74 couples undergoing GIFT for infertility.
- Pituitary desensitization was achieved using a GnRH analog prior to ovarian hyperstimulation with purified FSH and hMG.
- Ovarian response was monitored, and human chorionic gonadotropin (hCG) was administered when follicles reached >16 mm diameter with adequate estradiol levels.
- A maximum of 5 oocytes were transferred per patient.
Main Results:
- The overall success rate for GIFT across all conditions was 19%.
- Couples with unexplained sterility demonstrated a significantly higher success rate (31%) compared to those with male hypofertility (10%).
- The study identified that optimal GIFT outcomes were associated with estradiol (E2) levels exceeding 500 pg/ml per follicle >16 mm in diameter.
Conclusions:
- The Gamete Intrafallopian Transfer (GIFT) method is a valid and effective treatment for infertility.
- GIFT shows differential success rates depending on the underlying cause of infertility, being more effective for unexplained sterility.
- Careful monitoring of follicular development and hormonal profiles, particularly the E2 to follicle ratio, is crucial for maximizing GIFT success rates.