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Abnormal Papillary Muscle Signal on Cine MRI As a Typical Feature of Mitral Valve Prolapse

Alessandra Scatteia1, Carmine Emanuele Pascale1, Paolo Gallo1

  • 1Division of Cardiology "Villa dei Fiori" Hospital, Acerra, Na, Italy.

Scientific Reports
|June 10, 2020
PubMed
Abstract

Insights

Mitral valve prolapse (MVP) patients show a distinct "darker appearance" of papillary muscles on cardiac MRI. This finding, observed only in MVP, does not correlate with fibrosis or arrhythmias.

Area of Science:

  • Cardiovascular Imaging
  • Cardiac MRI
  • Valvular Heart Disease

Background:

  • Mitral valve prolapse (MVP) involves abnormal valvular apparatus movement.
  • This abnormality can impact papillary muscle (PM) structure and function.
  • Investigating PM signal characteristics in MVP is crucial for understanding disease mechanisms.

Purpose of the Study:

  • To investigate abnormal papillary muscle (PM) signals in patients with mitral valve prolapse (MVP).
  • To utilize cardiac magnetic resonance imaging (MRI) for assessing PM signal intensity.
  • To compare PM signals in MVP patients with healthy volunteers and other cardiac conditions.

Main Methods:

  • Cardiac MRI was performed on 47 consecutive MVP patients.
  • Papillary muscle (PM) signal intensity was normalized to left ventricular (LV) parietal myocardium.
  • Visual assessment and signal intensity analysis were conducted, comparing MVP patients to control groups.

Main Results:

  • Papillary muscle (PM) signal intensity was significantly lower in MVP patients compared to LV parietal myocardium.
  • This "darker appearance" of PMs was unique to the MVP group.
  • The reduced PM signal did not correlate with LV late gadolinium enhancement or a history of arrhythmias.

Conclusions:

  • A significantly reduced papillary muscle (PM) signal ('darker appearance') is a distinct finding in mitral valve prolapse (MVP) patients.
  • This MRI observation in MVP is not clearly linked to myocardial fibrosis or prior complex ventricular arrhythmias.
  • Cardiac MRI may reveal specific papillary muscle signal alterations in MVP, warranting further investigation.

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