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Related Experiment Video

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Precision Targeted Ablation of Fine Neurovascular Structures In Vivo Using Dual-mode Ultrasound Arrays.

Rajagopal N Aravalli1, Dusty Van Helden2, Dalong Liu1

  • 1Departments of Electrical and Computer Engineering, Minneapolis, MN, 55455, USA.

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|June 10, 2020
PubMed
Summary
This summary is machine-generated.

Focused ultrasound safely ablates carotid bodies in hypertensive rats, reducing blood pressure. This image-guided procedure shows promise for treating hypertension by targeting these key chemoreceptors.

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Area of Science:

  • Cardiovascular Research
  • Medical Imaging
  • Neurosurgery

Background:

  • Carotid bodies (CBs) are crucial chemoreceptors regulating breathing and blood pressure.
  • Enhanced CB activity is linked to hypertension, and CB removal can lower blood pressure.

Purpose of the Study:

  • To demonstrate the feasibility of using a dual-mode ultrasound array (DMUA) system for safe in vivo carotid body ablation in a rat model of hypertension.

Main Methods:

  • Utilized DMUA for 3D imaging to guide focused ultrasound (FUS) targeting of CBs at the carotid bifurcation.
  • Employed intermittent, high frame rate imaging for real-time monitoring of lesion formation during image-guided FUS (IgFUS).
  • Implemented closed-loop control (CLC) based on DMUA feedback to prevent overexposure and ensure safe ablation.

Main Results:

  • Successfully ablated CBs in over 100 spontaneously hypertensive rats (SHR) and normotensive rats using IgFUS.
  • Observed a measurable reduction in mean arterial pressure (MAP) 2-4 weeks post-treatment in rats that received unilateral CB ablation.
  • The procedure was well-tolerated in all treated animals.

Conclusions:

  • Direct unilateral FUS treatment of the carotid body is a feasible and potentially effective method for reducing blood pressure in hypertensive rats.
  • These findings support further investigation in larger animal models and eventual human clinical trials for hypertension management.