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Discovery of small-molecule enzyme activators by activity-based protein profiling

Bernard P Kok1, Srijana Ghimire2, Woojoo Kim1

  • 1Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, USA.

Nature Chemical Biology
|June 10, 2020
PubMed
Summary

Activity-based protein profiling (ABPP) now identifies enzyme activators, not just inhibitors. Researchers discovered a LYPLAL1 activator, demonstrating ABPP

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