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Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2
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An overview on COVID-19: reality and expectation
1Department of Therapeutic Chemistry, National Research Centre, El-Buhouth St., Dokki, Giza, Egypt.
Summary
The COVID-19 pandemic requires urgent diagnosis, vaccine development, and drug discovery. Precautionary measures remain crucial due to the lack of effective treatments against SARS-CoV-2.
Area of Science:
- Virology
- Epidemiology
- Public Health
Background:
- The rapid global spread of SARS-CoV-2 (COVID-19) poses a significant public health threat.
- Certain pre-existing conditions like diabetes and obesity increase susceptibility to severe COVID-19.
- There is an urgent need for effective diagnostic tools, vaccines, and treatments for COVID-19.
Purpose of the Study:
- To provide a comprehensive overview of COVID-19.
- To discuss future strategies for controlling the progression of the virus.
- To highlight the importance of diagnostics, vaccines, and therapeutics.
Main Methods:
- Review of current diagnostic methods, including RT-PCR.
- Examination of ongoing vaccine development efforts.
- Analysis of potential therapeutic agents and alternative treatments.
Main Results:
- Real-time PCR (RT-PCR) is a rapid and accurate diagnostic tool.
- Approximately 15 vaccine candidates are in global trials.
- Several existing drugs and alternative therapies are being investigated for COVID-19 treatment.
Conclusions:
- Precautionary measures are currently the primary strategy for managing the COVID-19 crisis.
- Continued research into vaccines and treatments is essential.
- Public health programs should prioritize at-risk populations for future viral outbreaks.
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