Related Experiment Video
Updated: Dec 18, 2025
Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
Chronic kidney disease could be a risk factor for thrombosis in essential thrombocythemia and polycythemia vera
Ivan Krečak1, Hrvoje Holik2,3, Morić Perić Martina4
1Department of Internal Medicine, Šibenik-Knin County General Hospital, Stjepana Radića 83, 22000, Šibenik, Croatia. krecak.ivan@gmail.com.
Insights
Chronic kidney disease (CKD) increases thrombosis risk in essential thrombocythemia (ET) and polycythemia vera (PV) patients. This finding suggests CKD may need inclusion in current risk assessments for these blood disorders.
Area of Science:
- Nephrology
- Hematology
- Cardiovascular Medicine
Background:
- Chronic kidney disease (CKD) is a known risk factor for venous thromboembolism and cardiovascular disease.
- The impact of CKD on thrombotic risk in essential thrombocythemia (ET) and polycythemia vera (PV) is not well understood.
Purpose of the Study:
- To investigate the correlation between CKD and thrombosis development in ET and PV patients.
- To assess the impact of CKD on thrombosis-free survival in ET and PV cohorts.
Main Methods:
- Retrospective multicenter study including 167 patients (76 ET, 91 PV).
- CKD defined as estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m² for ≥ 3 months.
- Analysis of clinical correlations and thrombosis-free survival using univariate and multivariate Cox regression models.
Main Results:
- 25.7% of patients had CKD at diagnosis.
- Lower eGFR correlated with advanced age, female sex, higher granulocytes, elevated C-reactive protein, prior thrombosis, CV risk factors, and splenomegaly.
- CKD was significantly associated with inferior thrombosis-free survival in the overall cohort and in both ET and PV subgroups, even after multivariate adjustment.
Conclusions:
- Chronic kidney disease may represent an independent risk factor for thrombosis in ET and PV patients.
- Further research with larger cohorts is necessary to validate these findings.
- Investigating the addition of CKD to existing risk stratification models may improve prognostication for ET and PV patients.
Abstract:
Chronic kidney disease (CKD) is a well-known risk factor for venous thromboembolism and cardiovascular (CV) disease development in the general population, but its role in thrombotic risk in essential thrombocythemia (ET) and polycythemia vera (PV) remains poorly understood. This retrospective multicenter study analyzed clinical correlations and the potential impact of CKD on thrombosis development in ET and PV patients. We included 167 patients (76 ET and 91 PV); 25.7% had CKD at diagnosis, defined as estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m2 for ≥ 3 months. Lower eGFR correlated with advanced age, female sex, higher granulocytes, higher serum C-reactive protein, history of thrombosis, CV risk factors, and the presence of palpable splenomegaly. CKD was univariately associated with inferior thrombosis-free survival in the entire cohort, as well as in both ET and PV patients. These results remained significant in the multivariate Cox regression models when adjusted to disease-specific risk models. Therefore, CKD could be a risk factor for thrombosis in ET and PV patients. Additional studies on a larger number of patients are needed to confirm our findings and to elucidate whether the addition of CKD to the current risk stratification models might improve prognostication in ET and PV patients.
Related Concept Videos
01:25Chronic Kidney Disease I: Introduction
01:24Chronic Kidney Disease II: Clinical Manifestations
01:28Chronic Kidney Disease III: Interprofessional Care
01:30Venous Thrombosis I: Introduction
01:18Chronic Kidney Disease IV: Nursing Management
01:29Acute Kidney Injury II: Pathophysiology