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Updated: Dec 18, 2025

Utilizing Murine Inducible Telomerase Alleles in the Studies of Tissue Degeneration/Regeneration and Cancer
Published on: April 13, 2015
Assessment of telomerase as drug target in breast cancer
Rishi Kumar Jaiswal1, Pramod Kumar Yadava
1Applied Molecular Biology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi 110 067, India.
Abstract:
Telomerase is a specialized enzyme which maintains telomere length at the extreme end of the chromosome. Over 90% of all cases of cancer show high expression of telomerase while in normal cells, its expression is extremely low or undetectable. Detection of telomerase activity in a wide range of breast cancer makes telomerase an interesting target for diagnosis and therapy. In this review, we have aimed to describe telomerase as a therapeutic and accurate diagnostic target in breast cancer. Telomerase performs many extracurricular activities apart from maintaining telomere length; here, we have also tried to address its role in epithelialmesenchymal transition (EMT) of breast cancer progression.
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