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Updated: Dec 18, 2025

Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier
Published on: February 8, 2017
Targeting specific cell organelles with different-faceted nanocrystals that are selectively recognized by
Qilin Yu1, Guizhu Wu, Tong Zhang
1College of Environmental Science & Eng., Nankai University, Tianjin 300350, China. liul@nankai.edu.cn chenwei@nankai.edu.cn.
Abstract:
Targeting specific cellular organelles is an elusive therapeutic goal that could be achieved by manipulating nanocrystal facets. As proof of concept, different facet-engineered nanonods (high-energy (001) CdS and (001) CdSe, and low-energy (101) CdS and (110) CdSe) exploited selective binding by organelle-targeting peptides and subsequent intracellular protein sorting to inhibit specific organelles without significant cytotoxicity.

