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Coronary artery ectasia: prevalence, angiographic characteristics and clinical outcome
Nadav Asher Willner1, Scott Ehrenberg2, Anees Musallam2
1Department of Cardiology, Rambam Health Care Campus, Haifa, Israel nadav.willner@gmail.com.
Insights
Coronary artery ectasia (CAE) is rare, often involving the right coronary artery. Patients with CAE and atherosclerotic heart disease face higher complication rates than those with isolated CAE.
Area of Science:
- Cardiology
- Vascular Medicine
Background:
- Coronary artery ectasia (CAE) is a rare vascular condition.
- Understanding its prevalence and clinical outcomes is crucial for patient management.
Purpose of the Study:
- To determine the prevalence of coronary artery ectasia (CAE).
- To evaluate the clinical outcomes of patients with CAE.
Main Methods:
- Retrospective analysis of 20,455 coronary angiograms performed between 2006 and 2017.
- Inclusion of patients diagnosed with CAE based on procedure reports.
- Follow-up assessment of adverse clinical events.
Main Results:
- CAE was diagnosed in 0.85% of patients (174 studies, 161 patients).
- The right coronary artery was most commonly involved (79%), with diffuse ectasia being the most frequent morphology (78.9%).
- Patients with mixed CAE and atherosclerotic heart disease (ASHD) had significantly higher adverse event rates (48.8%) compared to isolated CAE (25%).
Conclusions:
- Coronary artery ectasia is a rare condition, predominantly affecting the right coronary artery with diffuse morphology.
- Concomitant atherosclerotic heart disease in CAE patients is associated with increased mortality and complications.
- Management strategies differ, with conservative approaches for isolated CAE and interventions for mixed CAE-ASHD.
Objective:
Determine coronary artery ectasia (CAE) prevalence and clinical outcome in a large cohort of patients underwent coronary angiography.
Methods:
In an 11-year period, between 2006 and 2017, 20 455 coronary angiography studies were performed at a large university centre. Patients diagnosed with CAE based on procedure report were included in the final analysis.
Results:
CAE was diagnosed in 174 out of 20 455 studies (0.85% per total angiograms, 161 patients). Patients' average age was 59.6±11.2 years old with male predominance (90.7%). Diffuse ectasia morphology was most common (78.9%), followed by fusiform (16.1%) and saccular (5%). Mixed CAE and atherosclerotic heart disease (ASHD) was present in 75.2% of the patients and isolated CAE in 24.8%. The most common coronary artery involved was the right coronary artery (RCA) (79%). Following index angiography, all the isolated CAE group was managed conservatively, while 67% of the mixed CAE-ASHD group underwent coronary intervention. In an average follow-up of 6±3.6 years, adverse clinical event (a composite endpoint of any death, cerebrovascular accident, myocardial infarction, thromboembolic event, bleeding and stent thrombosis) occurred in 48.8% of the mixed CAE-ASHD group compared with 25% in the isolated CAE group (p<0.05).
Conclusions:
CAE is a rare phenomenon. The most common artery involved was the RCA, and the diffused type of CAE was the most frequent. Most patients with CAE have also concomitant ASHD, and those patients have higher mortality and complications rate, compared with isolated CAE disease.
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