Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Ventilatory Modes01:14

Ventilatory Modes

1.0K
Mechanical ventilators are life-saving devices that support or replace spontaneous breathing. They deliver breaths to patients through varying methods known as ventilator modes. Understanding these modes is critical for healthcare providers managing patients with respiratory failure.
There are three ventilatory modes: full support, partial support, and spontaneous. These are described below.
Full Support Modes
Full support modes include controlled mechanical ventilation, continuous mandatory...
1.0K
Pulmonary Ventilation: Inhalation01:24

Pulmonary Ventilation: Inhalation

6.9K
Pulmonary ventilation is a vital process that ensures the exchange of oxygen and carbon dioxide in the lungs. It refers to the movement of air into and out of the lungs, enabling the body to obtain oxygen and remove waste carbon dioxide. In this article, we will explore the intricacies of pulmonary ventilation, including its underlying principles, mechanisms, and the interplay of pressures within the respiratory system.
Boyle's law becomes particularly pertinent when examining respiratory...
6.9K
Pleura of the Lungs01:13

Pleura of the Lungs

5.6K
The lungs are nestled in a cavity, shielded by the pleura. The pleura, a form of serous membrane, wraps around each lung. This membrane arrangement consists of two layers: the visceral and parietal pleurae. The visceral pleura lines the surface of the lungIn contrast, the parietal pleura is the outer layer and contacts to the thoracic wall, the mediastinum, and the diaphragm. The hilum is the point of connection between the visceral and parietal layers. The space between the parietal and...
5.6K
Anatomy of Respiratory System II: Lower Respiratory Tract01:31

Anatomy of Respiratory System II: Lower Respiratory Tract

2.9K
The lower respiratory tract is anatomically composed of several vital structures, including the larynx, trachea, bronchial tree, alveoli, lungs, and pleurae. Each component has a specific function, and all are intricately connected to ensure efficient respiration.
The Larynx
It is located between the pharynx and the trachea, acts as a passageway for air, and hosts several critical structures, such as the epiglottis, vocal cords, and glottis. The epiglottis acts as a gateway, guiding food to the...
2.9K
Pulmonary Cycle: Exhalation01:17

Pulmonary Cycle: Exhalation

2.8K
In terms of human respiration, the act of expelling air, known as exhalation (or expiration), operates on the principle of pressure gradients. During expiration, the pressure within the lungs exceeds that of the surrounding atmosphere. Under normal conditions, quiet breathing involves passive exhalation and is free of muscular contractions. This is because the exhalation process is driven by the natural elastic recoil of the lungs and chest wall, both of which have an inherent tendency to...
2.8K
Mechanical Ventilation III: Noninvasive Ventilation01:23

Mechanical Ventilation III: Noninvasive Ventilation

433
Noninvasive positive-pressure ventilation (NIPPV), continuous positive airway pressure (CPAP), and bilevel positive airway pressure (BiPAP) are essential methods in respiratory care. These ventilation techniques offer unique benefits for patients with various respiratory conditions, providing adequate support without requiring intubation. Let's explore how each method is crucial in improving patient outcomes and enhancing respiratory therapy.
Noninvasive Positive-Pressure Ventilation...
433

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

ECMO for patients with obesity: evidence and practice.

Intensive care medicine·2026
Same author

Regional gas exchange evaluation during ex vivo lung perfusion in a swine model of localized lung dysfunction.

Animal models and experimental medicine·2026
Same author

Dyspnea as a marker of prognosis in immunocompromised patients with acute respiratory failure.

Annals of intensive care·2026
Same author

Reply to Fishler et al.

Journal of applied physiology (Bethesda, Md. : 1985)·2026
Same author

Definition and prognostic value of response to prone positioning in ARDS: a systematic review and meta-analysis.

Critical care (London, England)·2026
Same author

Optimizing endpoints in early phase clinical trials of acute respiratory distress syndrome.

American journal of respiratory and critical care medicine·2026
Same journal

How the Exposome Shapes Our Respiratory Health.

American journal of respiratory and critical care medicine·2026
Same journal

Diagnostic criteria for invasive pulmonary aspergillosis in COPD patients.

American journal of respiratory and critical care medicine·2026
Same journal

Opportunities for Human Lung Tissue-Based Studies in Fibrotic ILD Research.

American journal of respiratory and critical care medicine·2026
Same journal

Astegolimab in COPD: success or failure?

American journal of respiratory and critical care medicine·2026
Same journal

How artificial intelligence could improve the diagnosis and management of COPD: a perspective from GOLD.

American journal of respiratory and critical care medicine·2026
Same journal

Awake ECMO for ARDS: No Vent, No VILI, No Problem?

American journal of respiratory and critical care medicine·2026
See all related articles

Related Experiment Video

Updated: Dec 18, 2025

Author Spotlight: Unraveling the Impact of Mechanical Ventilation on Diaphragm Function and Patient Outcomes
05:51

Author Spotlight: Unraveling the Impact of Mechanical Ventilation on Diaphragm Function and Patient Outcomes

Published on: November 3, 2023

8.0K

Lung- and Diaphragm-Protective Ventilation.

Ewan C Goligher1,2,3, Martin Dres4,5, Bhakti K Patel6

  • 1Interdepartmental Division of Critical Care Medicine.

American Journal of Respiratory and Critical Care Medicine
|June 10, 2020
PubMed
Summary
This summary is machine-generated.

Mechanical ventilation can harm the diaphragm, leading to poor outcomes. A new approach integrates lung and diaphragm protection, prioritizing lung safety when conflicts arise, to improve patient recovery.

Keywords:
artificial respirationlung injurymechanical ventilationmyotrauma

More Related Videos

Normothermic Negative Pressure Ventilation Ex Situ Lung Perfusion: Evaluation of Lung Function and Metabolism
09:31

Normothermic Negative Pressure Ventilation Ex Situ Lung Perfusion: Evaluation of Lung Function and Metabolism

Published on: February 14, 2022

2.4K
Ex Vivo Porcine Experimental Model for Studying and Teaching Lung Mechanics
12:09

Ex Vivo Porcine Experimental Model for Studying and Teaching Lung Mechanics

Published on: April 19, 2024

1.9K

Related Experiment Videos

Last Updated: Dec 18, 2025

Author Spotlight: Unraveling the Impact of Mechanical Ventilation on Diaphragm Function and Patient Outcomes
05:51

Author Spotlight: Unraveling the Impact of Mechanical Ventilation on Diaphragm Function and Patient Outcomes

Published on: November 3, 2023

8.0K
Normothermic Negative Pressure Ventilation Ex Situ Lung Perfusion: Evaluation of Lung Function and Metabolism
09:31

Normothermic Negative Pressure Ventilation Ex Situ Lung Perfusion: Evaluation of Lung Function and Metabolism

Published on: February 14, 2022

2.4K
Ex Vivo Porcine Experimental Model for Studying and Teaching Lung Mechanics
12:09

Ex Vivo Porcine Experimental Model for Studying and Teaching Lung Mechanics

Published on: April 19, 2024

1.9K

Area of Science:

  • Critical Care Medicine
  • Respiratory Physiology
  • Mechanical Ventilation

Background:

  • Mechanical ventilation can lead to diaphragm atrophy and injury, negatively impacting patient outcomes.
  • Lung-protective ventilation is established, but diaphragm-protective strategies are emerging.
  • Expert consensus highlights the need for an integrated approach to mechanical ventilation.

Purpose of the Study:

  • To outline a conceptual framework for integrated lung- and diaphragm-protective mechanical ventilation.
  • To propose targets for diaphragm protection based on respiratory effort and patient-ventilator synchrony.
  • To discuss potential conflicts between lung and diaphragm protection and emphasize lung protection priority.

Main Methods:

  • Expert discussions convened by the Pleural Pressure Working Group (PLUG) of the European Society of Intensive Care Medicine.
  • Review of growing evidence on mechanisms of diaphragm injury during mechanical ventilation.
  • Development of a conceptual framework for a dual-protective ventilation strategy.

Main Results:

  • Proposed targets for diaphragm protection focusing on respiratory effort and patient-ventilator synchrony.
  • Identified potential conflicts between lung and diaphragm protection, with lung protection taking precedence.
  • Emphasized the necessity of monitoring respiratory effort for concurrent protection.

Conclusions:

  • Integrated lung- and diaphragm-protective ventilation requires new monitoring, ventilator settings, and sedation titration strategies.
  • Adjunctive interventions like extracorporeal life support and phrenic nerve stimulation may benefit selected patients.
  • This new paradigm offers a potential opportunity to improve clinical outcomes in critically ill patients, though evaluation presents challenges.