The effect of the perfluorodecalin patch on particle emission and skin temperature during laser-induced tattoo...

Laser-based procedures for tattoo removals are popular due to high efficacy and a relatively moderate insult. However, it often requires multiple sessions to achieve a satisfactory effect. The perfluorodecalin (PFD) patch utilizes an optical clearing agent to speed up the removal process and may decrease skin insult and harmful particles emission during treatment. This study assessed in pigs the effect of the PFD patch in connection with laser treatment of skin with and without tattoos to determine whether the PFD patch provides benefit in lowering thermal skin insult and particle emission during treatment. Skin temperature measured by infrared thermometer during laser treatment or shortly thereafter showed a significant (approximately 40%) decrease with the PFD patch in sites with tattoos. For laser-treated sites without tattoos, there was a significant decrease of particles observed with the PFD patch. In laser-treated sites with tattoos, a strong trend was seen (approximately a twofold decrease) but did not reach statistical significance due to high variability. The present data show that the PFD patch limits the increase in skin temperature produced with laser during treatment. Moreover, it decreases the emission of particles in sites without tattoos and is suggestive of a similar effect in sites with tattoos.