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Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer
Published on: November 2, 2013
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Implementation of Germline Testing for Prostate Cancer: Philadelphia Prostate Cancer Consensus Conference 2019.
Veda N Giri1,2,3, Karen E Knudsen3, William K Kelly1
1Department of Medical Oncology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA.
Summary
Germline testing (GT) is crucial for prostate cancer (PCA) management. This framework offers updated guidance on multigene panel testing, hereditary risk assessment, and genetic counseling strategies for precision oncology.
Area of Science:
- Genetics
- Oncology
- Precision Medicine
Background:
- Germline testing (GT) is integral to prostate cancer (PCA) treatment, management, and hereditary cancer assessment.
- Current challenges include optimizing multigene testing, standardizing GT indications, and addressing the growing demand for genetic services.
Framework:
- A multidisciplinary consensus conference developed a genetic implementation framework using a modified Delphi model.
- Recommendations include large germline panels and somatic testing for metastatic PCA, with reflex testing strategies.
- Criteria for GT indications and management were established with strong or moderate consensus.
Implementation:
- Priority genes for metastatic PCA treatment include BRCA2, BRCA1, and mismatch repair genes; broader testing for ATM is suggested for clinical trials.
- BRCA2 is recommended for active surveillance discussions; screening guidelines are provided for carriers.
- Collaborative point-of-care evaluation models and technology-based approaches are endorsed to address genetic counseling shortages.
Implications:
- This consensus-driven framework provides novel guidance for clinicians and patients in the precision era of PCA care.
- Further research, education, and policy development are needed to fully implement these genetic strategies.
