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Related Experiment Video

Updated: Dec 18, 2025

Non-invasive Assessment of Microvascular and Endothelial Function
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Blood pressure variability and microvascular dysfunction: the Maastricht Study.

Tan Lai Zhou1,2, Sytze P Rensma1,2, Frank C T van der Heide1,2

  • 1Department of Internal Medicine, Maastricht University Medical Centre.

Journal of Hypertension
|June 10, 2020
PubMed
Summary
This summary is machine-generated.

Greater blood pressure variability (BPV) is linked to kidney microvascular damage, indicated by higher albuminuria. This study suggests kidney microvasculature may be most susceptible to BPV effects, impacting chronic kidney disease risk.

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Area of Science:

  • Cardiovascular Research
  • Nephrology
  • Vascular Biology

Background:

  • Microvascular dysfunction (MVD) is implicated in stroke, dementia, depression, retinopathy, and chronic kidney disease.
  • The precise determinants of MVD remain incompletely understood.
  • Elevated blood pressure variability (BPV) is a potential contributing factor to MVD.

Purpose of the Study:

  • To investigate the association between very short- to mid-term BPV and various MVD measures.
  • To determine if heightened BPV is a risk factor for microvascular damage across different organ systems.
  • To identify which microvascular beds are most affected by BPV.

Main Methods:

  • Cross-sectional analysis of 2773 participants from The Maastricht Study (mean age 59.9 years).
  • Standardized and averaged systolic and diastolic BPV composite scores from within-visit, 24-h, and 7-day measurements.
  • MVD assessment included cerebral small vessel disease (CSVD) features via MRI, retinal vascular response, albuminuria, skin hyperemia, and plasma biomarkers.

Main Results:

  • Higher systolic and diastolic BPV composite scores were significantly associated with increased albuminuria.
  • No significant associations were found between higher BPV and CSVD features, retinal vascular response, skin hyperemia, or plasma MVD biomarkers.
  • The findings indicate a specific link between BPV and kidney microvascular health.

Conclusions:

  • Increased BPV is associated with kidney microvascular dysfunction, as evidenced by higher albuminuria.
  • The study suggests that the kidney's microvasculature may be particularly vulnerable to the adverse effects of elevated BPV.
  • Further research is warranted to explore the mechanisms linking BPV to albuminuria and its implications for chronic kidney disease.