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Octahedral Molybdenum Cluster Complexes with Optimized Properties for Photodynamic Applications.
Kaplan Kirakci1, Jaroslav Zelenka2, Ivana Křížová3
1Institute of Inorganic Chemistry of the Czech Academy of Sciences, Řež 1001, 250 68 Husinec-Řež, Czech Republic.
Inorganic Chemistry
|June 10, 2020
Summary
Two novel molybdenum complexes efficiently generate singlet oxygen for photodynamic cancer therapy. These compounds show promise for in vivo applications due to their stability and effectiveness under blue light.
Area of Science:
- Inorganic Chemistry
- Materials Science
- Photochemistry
Background:
- Photodynamic therapy (PDT) is a promising cancer treatment modality.
- Development of efficient photosensitizers is crucial for PDT efficacy.
- Molybdenum-based clusters offer unique electronic and structural properties.
Purpose of the Study:
- To synthesize and characterize novel octahedral molybdenum cluster complexes.
- To evaluate their potential as singlet oxygen (SO) suppliers for photodynamic therapy (PDT).
- To assess their cellular uptake, phototoxicity, and stability in biological media.
Main Methods:
- Synthesis of octahedral molybdenum cluster complexes with {Mo6I8}4+ core.
- Characterization using 1H NMR, HR ESI-MS, and CHN elemental analysis.
- Evaluation of luminescence quantum yields, singlet oxygen generation, and cellular studies (uptake, phototoxicity, serum stability).
Main Results:
- Two new molybdenum cluster complexes were successfully synthesized and characterized.
- Both complexes demonstrated high quantum yields for luminescence and singlet oxygen formation in aqueous solutions.
- The complexes exhibited efficient internalization into HeLa cells, potent phototoxicity under blue light, and stability in fetal bovine serum.
Conclusions:
- The novel molybdenum cluster complexes are efficient singlet oxygen generators.
- They show significant potential as photosensitizers for photodynamic cancer therapy.
- Their stability and efficacy in biological environments suggest promise for in vivo applications.
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