Jove
Visualize
Contact Us

Related Concept Videos

Neurulation01:30

Neurulation

44.7K
Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the...
44.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Selective regulation of transsynaptic alignment and postsynaptic assembly by a novel NCAM family synaptic adhesion molecule.

bioRxiv : the preprint server for biology·2026
Same author

β-Amyloid induces microglial expression of GPC4 and APOE leading to increased neuronal tau pathology and toxicity.

Molecular neurodegeneration·2025
Same author

Selective life-long suppression of an odor processing channel in response to critical period experience.

bioRxiv : the preprint server for biology·2025
Same author

β-Amyloid Induces Microglial Expression of GPC4 and APOE Leading to Increased Neuronal Tau Pathology and Toxicity.

bioRxiv : the preprint server for biology·2025
Same author

Glia control experience-dependent plasticity in an olfactory critical period.

eLife·2025
Same author

EVs move messes, not messages, at the synapse.

The Journal of cell biology·2024
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Dec 18, 2025

Induction of Protein Deletion Through In Utero Electroporation to Define Deficits in Neuronal Migration in Transgenic Models
12:01

Induction of Protein Deletion Through In Utero Electroporation to Define Deficits in Neuronal Migration in Transgenic Models

Published on: January 12, 2015

10.5K

Pyroptosis Takes Aim at Neurodevelopment.

Jaeda C Coutinho-Budd1, Heather T Broihier2

  • 1Department of Biology, University of Vermont, Burlington, VT 05405, USA.

Developmental Cell
|June 10, 2020
PubMed
Summary
This summary is machine-generated.

DNA damage triggers AIM2-mediated pyroptosis, a form of cell death, during brain development. This process prevents adult anxiety-like behaviors, highlighting non-apoptotic cell death

More Related Videos

Author Spotlight: Flow Cytometric Determination of Pyroptosis in Avian Cells
05:14

Author Spotlight: Flow Cytometric Determination of Pyroptosis in Avian Cells

Published on: May 31, 2024

1.9K
Immunohistochemical Visualization of Hippocampal Neuron Activity After Spatial Learning in a Mouse Model of Neurodevelopmental Disorders
07:43

Immunohistochemical Visualization of Hippocampal Neuron Activity After Spatial Learning in a Mouse Model of Neurodevelopmental Disorders

Published on: May 12, 2015

11.6K

Related Experiment Videos

Last Updated: Dec 18, 2025

Induction of Protein Deletion Through In Utero Electroporation to Define Deficits in Neuronal Migration in Transgenic Models
12:01

Induction of Protein Deletion Through In Utero Electroporation to Define Deficits in Neuronal Migration in Transgenic Models

Published on: January 12, 2015

10.5K
Author Spotlight: Flow Cytometric Determination of Pyroptosis in Avian Cells
05:14

Author Spotlight: Flow Cytometric Determination of Pyroptosis in Avian Cells

Published on: May 31, 2024

1.9K
Immunohistochemical Visualization of Hippocampal Neuron Activity After Spatial Learning in a Mouse Model of Neurodevelopmental Disorders
07:43

Immunohistochemical Visualization of Hippocampal Neuron Activity After Spatial Learning in a Mouse Model of Neurodevelopmental Disorders

Published on: May 12, 2015

11.6K

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Immunology

Background:

  • Normal brain development involves intricate cellular processes.
  • Cell death mechanisms play crucial roles in shaping neural circuits.
  • Aberrant neurodevelopment is linked to behavioral disorders.

Purpose of the Study:

  • To investigate the role of DNA damage in normal brain development.
  • To explore the involvement of AIM2-mediated pyroptosis in neurodevelopment.
  • To determine the impact of these processes on anxiety-like behaviors.

Main Methods:

  • Utilizing mouse models to study brain development.
  • Employing genetic and molecular techniques to analyze DNA damage.
  • Assessing pyroptosis activation and its downstream effects.
  • Evaluating anxiety-like behaviors in adult subjects.

Main Results:

  • DNA damage was found to activate AIM2-mediated pyroptosis during normal brain development.
  • This AIM2-mediated pyroptosis was essential for preventing the acquisition of anxiety-like behaviors.
  • The study identified a critical role for non-apoptotic cell death in neurodevelopmental processes.

Conclusions:

  • AIM2-mediated pyroptosis, driven by DNA damage, is a key mechanism in normal brain development.
  • This pathway is crucial for regulating emotional behaviors later in life.
  • Non-apoptotic cell death pathways are vital for healthy neurodevelopment and behavioral outcomes.