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Updated: Dec 18, 2025

Eye Removal in Living Zebrafish Larvae to Examine Innervation-dependent Growth and Development of the Visual System
Published on: February 11, 2022
Separate ON and OFF pathways in vertebrate vision first arose during the Cambrian
Erika M Ellis1, Rikard Frederiksen1, Ala Morshedian1
1Department of Ophthalmology and Jules Stein Eye Institute, University of California Los Angeles, Los Angeles, CA 90095, USA.
Abstract:
Ellis et al. show that retinal ON and OFF bipolar cells, and the novel metabotropic glutamate receptors of ON bipolar-cell dendrites, are both present in lamprey. They conclude that the fundamental organizing principle of separate ON and OFF pathways first appeared in the vertebrate visual system over 500 million years ago in the late Cambrian.
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