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Neurobiology: Crowdsourcing CO2 to Conserve Brain Energy
Ewan St John Smith1, Thomas J Park2
1Department of Pharmacology, University of Cambridge, Cambridge CB2 1PD, UK.
Abstract:
Naked mole-rats are adapted to living in a low-oxygen and high-CO2 environment. Elevated environmental CO2 inhibits brain activity and has acted as a selection pressure to reduce GABAergic tone, which in turn reduces energetic needs in a hypoxic habitat.
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