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A Multidisciplinary Review of the Roles of Cripto in the Scientific Literature Through a Bibliometric Analysis of its
Elisa Rodrigues Sousa1, Eugenio Zoni1,2, Sofia Karkampouna1
1Department for Biomedical Research, Urology Research Laboratory, University of Bern, 3008 Bern, Switzerland.
Abstract:
Cripto is a small glycosylphosphatidylinisitol (GPI)-anchored and secreted oncofetal protein that plays important roles in regulating normal physiological processes, including stem cell differentiation, embryonal development, and tissue growth and remodeling, as well as pathological processes such as tumor initiation and progression. Cripto functions as a co-receptor for TGF-β ligands such as Nodal, GDF1, and GDF3. Soluble and secreted forms of Cripto also exhibit growth factor-like activity and activate SRC/MAPK/PI3K/AKT pathways. Glucose-Regulated Protein 78 kDa (GRP78) binds Cripto at the cell surface and has been shown to be required for Cripto signaling via both TGF-β and SRC/MAPK/PI3K/AKT pathways. To provide a comprehensive overview of the scientific literature related to Cripto, we performed, for the first time, a bibliometric analysis of the biological roles of Cripto as reported in the scientific literature covering the last 10 years. We present different fields of knowledge in comprehensive areas of research on Cripto, ranging from basic to translational research, using a keyword-driven approach. Our ultimate aim is to aid the scientific community in conducting targeted research by identifying areas where research has been conducted so far and, perhaps more importantly, where critical knowledge is still missing.
Insights
This bibliometric analysis maps the 10-year research landscape of Cripto, an oncofetal protein crucial for cell growth and tumor progression. It identifies research gaps to guide future scientific investigations.
Area of Science:
- Biochemistry
- Molecular Biology
- Oncology
Background:
- Cripto is a small, secreted oncofetal protein involved in normal development and cancer.
- It acts as a co-receptor for TGF-β ligands and activates key signaling pathways.
- Glucose-Regulated Protein 78 kDa (GRP78) is essential for Cripto-mediated signaling.
Purpose of the Study:
- To conduct the first bibliometric analysis of Cripto research over the past decade.
- To map the scientific literature on Cripto's biological roles.
- To identify research trends and knowledge gaps in Cripto biology.
Main Methods:
- Bibliometric analysis of scientific literature.
- Keyword-driven approach to categorize research areas.
- Analysis covering the last 10 years of published research.
Main Results:
- Comprehensive overview of research fields related to Cripto.
- Categorization of studies from basic science to translational research.
- Identification of areas with substantial research and areas needing further investigation.
Conclusions:
- The study provides a structured overview of Cripto research.
- It highlights the importance of Cripto in both physiological and pathological processes.
- The findings aim to assist researchers in focusing future Cripto-related studies effectively.
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