A Spray-Dried, Co-Processed Rice Starch as a Multifunctional Excipient for Direct Compression
Karnkamol Trisopon1, Nisit Kittipongpatana1,2, Ornanong Suwannapakul Kittipongpatana1,2
1Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand.
Pharmaceutics
|June 11, 2020
Summary
A novel co-processed rice starch excipient (CS) demonstrates enhanced flowability, compressibility, and rapid disintegration for tablet manufacturing. This multifunctional excipient shows promising characteristics compared to commercial options.
Area of Science:
- Pharmaceutical Technology
- Materials Science
- Chemical Engineering
Background:
- Traditional excipients face limitations in tablet manufacturing.
- Development of novel excipients is crucial for improving drug delivery systems.
- Rice starch offers a sustainable and biocompatible base for excipient development.
Purpose of the Study:
- To develop and characterize a new co-processed rice starch-based excipient (CS) using spray-drying.
- To evaluate the impact of cross-linked carboxymethyl rice starch (CCMS) and silicon dioxide on CS properties.
- To compare the performance of the developed CS with commercial direct compression (DC) excipients.
Main Methods:
- Co-processing of native rice starch (RS) with CCMS and silicon dioxide via spray drying.
- Characterization of spherical agglomerates for improved flowability.
- Compressibility studies to assess plastic deformation, compaction, and tensile strength.
- Evaluation of tablet disintegration time and comparison with commercial excipients (Prosolv®, Tablettose®).
Main Results:
- The developed CS exhibited spherical agglomerates with improved flowability.
- CS demonstrated enhanced plastic deformation, leading to better compaction and tensile strength.
- The optimal formulation (CS-CCMS:SiO2 (10:2.7)) showed comparable flow to Prosolv® and Tablettose®, superior tensile strength to Tablettose®, and rapid disintegration (28s) compared to Prosolv® (>30 min).
Conclusions:
- Co-processed rice starch excipients (CS) possess multifunctional properties suitable for direct compression tablet manufacturing.
- The developed CS offers a promising alternative to commercial excipients, particularly for applications requiring rapid disintegration.
- Further investigation into CS applications in various pharmaceutical formulations is warranted.
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