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Updated: Dec 18, 2025

Biosynthesis of a Flavonol from a Flavanone by Establishing a One-pot Bienzymatic Cascade
Published on: August 14, 2019
Corynanthean-Epicatechin Flavoalkaloids from Corynanthe pachyceras
Tapé Kouamé1,2, Aboua Timothée Okpekon2, Nicaise F Bony3
1Université Paris-Saclay, CNRS, BioCIS, 92290 Châtenay-Malabry, France.
Abstract:
Epicatechocorynantheines A and B, and epicatechocorynantheidine were isolated from the stem bark of Corynanthe pachyceras. These molecules were pinpointed, and their isolation streamlined, by a molecular networking strategy. The structural elucidation was unambiguously accomplished from HRMS and 1D/2D NMR data. These compounds represent the first examples of corynanthean-type alkaloids tethered with a flavonoid. Epicatechocorynantheidine notably instigated two connections between the monoterpene indole alkaloid and the flavonoid, yielding an unprecedented octacyclic appendage. These flavoalkaloids exerted moderate antiplasmodial activities.
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