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Bluish-gray fingernail discoloration due to the use of nivolumab
Miguel Michel Ocampo1, Jaren Lerner1, Constantin A Dasanu2,3
1Department of Internal Medicine, Eisenhower Health, Rancho Mirage, USA.
Introduction:
Immune checkpoint inhibitors have improved clinical outcomes in a wide range of cancers. While skin toxicity is not uncommon with immune checkpoint inhibitors, generalized nail discoloration has not been reported with their use in oncology.
Case Report:
Herein, we report a unique case of bluish-gray fingernail discoloration due to nivolumab therapy for relapsed melanoma.Management and outcome: This condition reversed completely 10 weeks after nivolumab discontinuation. Naranjo nomogram assessment renders the causality relationship between nivolumab and nail discoloration probable.
Discussion:
To our knowledge, this is the first case report of an unusual bluish-gray nail discoloration due to therapy with nivolumab. The mechanism by which nivolumab causes this side effect remains to be elucidated.
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