Molecular interaction of non-steroidal compounds with uterine progesterone receptor (Part II)

Some possible non-steroidal antiprogestins were evaluated for their receptor binding activity by competitive protein binding assay in rabbit as well as human uterine cytosol in vitro. Of the 42 compounds belonging to 5 different series tested, dimethyl ester of monobenzylidene succinic acid, 4-ethoxycarbonyl-3-(m-methoxybenzyl)-5-(m-anisyl)-gamma-butyrolact one and 2-(3-benzyl-oxybenzyl)-3-(3-acetoxybenzyl)butane-1,4-diol exhibit around 20% inhibition of 3H-progesterone binding to uterine cytosol in both species.