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Updated: Dec 18, 2025

A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence
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Role of immune cells in the removal of deleterious senescent cells

Abhijit Kale1, Amit Sharma2, Alexandra Stolzing2,3

  • 1Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945 USA.

Immunity & Ageing : I & A
|June 11, 2020
PubMed

Insights

Cellular senescence, a state of irreversible cell cycle arrest, can drive aging. This review explores using immune cell therapies to eliminate these senescent cells and their harmful secretory phenotype.

Area of Science:

  • Cellular biology
  • Immunology
  • Aging research

Background:

  • Cellular senescence is a state of irreversible cell cycle arrest.
  • Senescence-associated secretory phenotype (SASP) has dual roles in tissue repair and aging.
  • Accumulation of senescent cells and SASP contributes to age-related pathologies.

Purpose of the Study:

  • To review the potential of immune cell-based therapies for senescent cell removal.
  • To discuss the adaptation of existing cancer immunotherapies for targeting senescent cells.

Main Methods:

  • Literature review of cellular senescence, SASP, and immune cell therapies.
  • Analysis of current cell-based therapeutic strategies for cancer.
  • Exploration of mechanisms for targeting senescent cells with immune cells.

Main Results:

  • Senescent cells and their SASP can be detrimental in aging.
  • Immune cell-based therapies offer a promising strategy for senescent cell clearance.
  • Existing cancer immunotherapies may be adaptable for senolytic purposes.

Conclusions:

  • Targeting senescent cells with immune therapies is a viable strategy to combat aging phenotypes.
  • Repurposing cancer immunotherapies could accelerate the development of senolytic treatments.
  • Further research is needed to optimize immune cell-based senolysis.
Keywords:
Age-related pathologyCell-based therapyCellular senescenceImmune surveillanceInflammationMacrophagesNatural killer cells

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