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Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

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Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
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Endocarditis II: Clinical Features of Infective Endocarditis01:25

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Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
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Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

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Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
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Nephrotic Syndrome II : Assessment and Medical Management01:26

Nephrotic Syndrome II : Assessment and Medical Management

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IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
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Nephrotic Syndrome III : Nursing Management01:24

Nephrotic Syndrome III : Nursing Management

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Nursing management for nephrotic syndrome adapts as the disease progresses, with strategies evolving to address advancing symptoms and complications.Early-Stage Management In the early stages, nursing interventions for nephrotic syndrome resemble those used in managing acute glomerulonephritis, focusing on symptom monitoring, fluid balance, and managing mild to moderate edema.Vital Signs: Regularly monitor blood pressure, pulse, respiratory rate, and temperature to promptly identify...
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Peripheral Artery Disease I: Introduction01:30

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Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
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Updated: Dec 18, 2025

Anti-Nuclear Antibody Screening Using HEp-2 Cells
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Polyarteritis nodosa with genital necrosis.

Paula Grinstein1, Lopez Silva Maximiliano2,3, Yirula Lucas4

  • 1Urology Resident, Hospital de Clínicas José de San Martín, Buenos Aires, Argentina.

Urology Case Reports
|June 11, 2020
PubMed
Summary

Polyarteritis nodosa (PAN), a rare multisystemic vasculitis, can affect the genitals. This case highlights successful immunosuppressive treatment for PAN presenting with penile and scrotal necrosis.

Keywords:
Chronic epididymitisNecrosisPolyarteritis nodosaVacuum-assistedVasculitis

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Area of Science:

  • Vascular Medicine
  • Rheumatology
  • Dermatology

Background:

  • Polyarteritis nodosa (PAN) is a systemic necrotizing vasculitis affecting small to medium-sized arteries.
  • Genital involvement in PAN is uncommon, making diagnosis challenging.

Observation:

  • A patient presented with systemic symptoms and significant genital manifestations, including penile and scrotal skin necrosis.
  • Biopsies of the testicles and glans confirmed necrotizing vasculitis consistent with PAN.

Findings:

  • The patient received a diagnosis of Polyarteritis nodosa (PAN).
  • Treatment involved a 6-week course of immunosuppressive therapy.

Implications:

  • This case underscores the importance of considering PAN in patients with unexplained genital necrosis.
  • Prompt diagnosis and immunosuppressive treatment can lead to favorable outcomes in rare presentations of PAN.